Research articles (Dept of Pathology)
http://hdl.handle.net/10311/1266
2024-03-28T17:24:05ZFibroadenoma in the axillary accessory breast
http://hdl.handle.net/10311/2253
Fibroadenoma in the axillary accessory breast
Motsumi, M.; Narasimhamurthy, M.; Gabolwelwe, M.
A 30-year-old female noted a mass in her right axilla for 6 years. The mass was painless, slowly growing,
causing discomfort, had cyclical changes in consistency and was of cosmetic concern to the patient. Examination revealed normal breasts and a soft, non-tender, broad based mass in the right axilla. Sonography was non-diagnostic. Diagnostic doubt, cosmetic concern and discomfort to the patient prompted excisional biopsy which revealed a 1 cm fibroadenoma with surrounding breast tissue and a diagnosis of fibroadenoma arising in accessory breast tissue was made. Surgical excision is recommended for symptomatic accessory breast tissue where diagnostic doubt exists and for cosmetic reasons.
2018-09-01T00:00:00ZImpact of human immunodeficiency virus infection on survival and acute toxicities from chemoradiation therapy for cervical cancer patients in a limited-resource setting
http://hdl.handle.net/10311/2251
Impact of human immunodeficiency virus infection on survival and acute toxicities from chemoradiation therapy for cervical cancer patients in a limited-resource setting
Grover, Surbhi; Yeager, Alyssa; Chiyapo, Sebathu; Bhatia, Rohini; MacDuffie, Emily; Puri, Priya; Balang, Dawn; Ratcliffe, Sarah; Narasimhamurthy, Mohan; Gwangwava, Elliphine; Tsietso, Sylvia; Kayembe, Mukendi K.A.; Ramogola-Masire, Doreen; Dryden-Peterson, Scott; Lin, Lilie L.; Zetola, Nicola M.; Viswanathan, Akila N.; Mahantshetty, Umesh
Purpose—To prospectively compare survival between human immunodeficiency virus (HIV)-infected versus HIV-uninfected cervical cancer patients who initiated curative chemoradiation therapy (CRT) in a limited-resource setting.
Methods and Materials—Women with locally advanced cervical cancer with or without HIV infection initiating radical CRT in Botswana were enrolled in a prospective, observational, cohort study from July 2013 through January 2015.
Results—Of 182 women treated for cervical cancer during the study period, 143 women initiating curative CRT were included in the study. Eighty-five percent of the participants (122 of 143) had stage II/III cervical cancer, and 67% (96 of 143) were HIV-infected. All HIV-infected patients were receiving antiretroviral therapy (ART) at the time of curative cervical cancer treatment initiation. We found no difference in toxicities between HIV-infected and HIV-uninfected women. The 2-year overall survival (OS) rates were 65% for HIV-infected women (95% confidence interval [CI] 54%-74%) and 66% for HIV-uninfected women (95% CI 49%-79%) (P = .70). Factors associated with better 2-year OS on multivariate analyses included baseline hemoglobin >10 g/dL (hazard ratio [HR] 0.37, 95% CI 0.19-0.72, P = .003), total radiation dose ≥75 Gy (HR 0.52, 95% CI 0.27-0.97, P = .04), and age <40 years versus 40-59 years (HR 2.17, 95% CI 1.05-4.47, P = .03).
Conclusions—Human immunodeficiency virus status had no effect on 2-year OS or on acute toxicities in women with well-managed HIV infection who initiated curative CRT in Botswana. In our cohort, we found that baseline hemoglobin levels, total radiation dose, and age were associated with survival, regardless of HIV status.
2018-05-01T00:00:00Z