Please use this identifier to cite or link to this item: http://hdl.handle.net/10311/2185
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dc.contributor.authorDrysen-Peterson, Scott-
dc.contributor.authorBvochora-Nsingo, Memory-
dc.contributor.authorSuneja, Gita-
dc.contributor.authorEfstathiou, Jason, A.-
dc.contributor.authorGrover, Surbhi-
dc.contributor.authorChiyapo, Sebathu-
dc.contributor.authorRamogola-Masire, Doreen-
dc.contributor.authorKebabonye-Pusoentsi, Malebogo-
dc.contributor.authorClayman, Rebecca-
dc.contributor.authorMapes, Abigail, C.-
dc.contributor.authorTapela, Neo-
dc.contributor.authorAsmelash, Aida-
dc.contributor.authorMedhin, Heluf-
dc.contributor.authorViswanathan, Akila, N.-
dc.contributor.authorRussell, Anthony H.-
dc.contributor.authorLin, Lilie, L.-
dc.contributor.authorKayembe, Mukendi K.A.-
dc.contributor.authorMmalane, Mompati-
dc.contributor.authorRandall, Thomas C.-
dc.contributor.authorChabner, Bruce-
dc.contributor.authorLockman, Shahin-
dc.date.accessioned2021-10-08T13:30:05Z-
dc.date.available2021-10-08T13:30:05Z-
dc.date.issued2016-08-29-
dc.identifier.citationDryden-Peterson, S, et al. (2016), HIV infection and survival among women with cervical cancer. Journal of Clinical Oncology, Vol. 34, No. 31, pp. 3749-3757en_US
dc.identifier.issn1527-7755 (electronic)-
dc.identifier.issn0732-183X (print)-
dc.identifier.urihttp://hdl.handle.net/10311/2185-
dc.description.abstractPurpose Cervical cancer is the leading cause of cancer death among the 20 million women with HIV worldwide. We sought to determine whether HIV infection affected survival in women with invasive cervical cancer. Patients and Methods We enrolled sequential patients with cervical cancer in Botswana from 2010 to 2015. Standard treatment included external beam radiation and brachytherapy with concurrent cisplatin chemotherapy. The effect of HIV on survival was estimated by using an inverse probability weighted marginal Cox model. Results A total of 348 women with cervical cancer were enrolled, including 231 (66.4%) with HIV and 96 (27.6%) without HIV. The majority (189 [81.8%]) of women with HIV received antiretroviral therapy before cancer diagnosis. The median CD4 cell count for women with HIV was 397 (interquartile range, 264 to 555). After a median follow-up of 19.7 months, 117 (50.7%) women with HIV and 40 (41.7%) without HIV died. One death was attributed to HIV and the remaining to cancer. Three-year survival for the women with HIV was 35% (95% CI, 27% to 44%) and 48% (95% CI, 35% to 60%) for those without HIV. In an adjusted analysis, HIV infection significantly increased the risk for death among all women (hazard ratio, 1.95; 95% CI, 1.20 to 3.17) and in the subset that received guideline-concordant curative treatment (hazard ratio, 2.63; 95% CI, 1.05 to 6.55). The adverse effect of HIV on survival was greater for women with a more-limited stage cancer (P = .035), those treated with curative intent (P = .003), and those with a lower CD4 cell count (P = .036). Advanced stage and poor treatment completion contributed to high mortality overall. Conclusion In the context of good access to and use of antiretroviral treatment in Botswana, HIV infection significantly decreases cervical cancer survival.en_US
dc.description.sponsorshipSupported by National Institutes of Health Grants No. P30AI060354, P30AI045008, and K23AI091434; National Cancer Institute Federal Share of program income earned by Massachusetts General Hospital on C06CA059267; and the Paul G. Allen Family Foundation (11689).en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Clinical Oncology, https://beta.asco.org/en_US
dc.rightsThis item is distributed under the Creative Commons Licenses, CC BY, CC BY-NC-NDen_US
dc.subjectCervical canceren_US
dc.subjectAntiretroviral therapyen_US
dc.subjectCancer diagnosisen_US
dc.subjectCervical cancer survivalen_US
dc.subjectAntiretroviral treatmenten_US
dc.subjectHIV infectionen_US
dc.subjectBotswanaen_US
dc.titleHIV infection and survival among women with cervical canceren_US
dc.typePublished Articleen_US
dc.rights.holderAmerican Society of Clinical Oncologyen_US
dc.linkhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477924/en_US
Appears in Collections:Research articles (Dept of Obstetrics & Gynaecology)

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