Diterpenoids from the stem bark of Croton zambesicus

Please use this identifier to cite or link to this item: http://hdl.handle.net/10311/251

Title:	Diterpenoids from the stem bark of Croton zambesicus
Authors:	Ngadjui, B.T. Abegaz, B.M. Keumedjio, F. Folefoc, G.N. Kapchec, G.W.F.
Keywords:	Croton zambesicus Euphorbiaceae Stem bark Isolation; Clerodane Crotozambefurans A, B and C
Issue Date:	2002
Publisher:	Elsevier Science Ltd. www.elsevier.com/locate/phytochem
Citation:	Ngadjui, B.T. et al (2002) Diterpenoids from the stem bark of Croton zambesicus, Phytochemistry, vol. 60, pp. 345–349
Abstract:	Three clerodane diterpenoids, crotozambefurans A, B and C were isolated from the stem bark of Croton zambesicus together with the known clerodane crotocorylifuran and two trachylobanes: 7b-acetoxytrachyloban-18-oic acid and trachyloban-7b, 18-diol. Betulinol, lupeol, sitosterol and its 3b-glucopyranosyl derivative were also obtained. The structures of crotozambefurans A, B and C were determined, respectively, as: 15,16-epoxy-1,3,13(16),14-clerodatetraen-20,12-olide-18,19-dioic acid dimethylester, 15,16-epoxy- 1,3,13(16),14-clerodatetraen-18,19,20-trioic acid trimethylester and 15,16-epoxy-3,13(16),14-clerodatrien-19,1a:20,12-diolide-18-oic acid methylester, using spectroscopic analysis, especially, NMR spectra in conjunction with 2D experiments, COSY, HSQC, HMBC and TOCSY.
URI:	http://hdl.handle.net/10311/251
ISSN:	0031-9422
Appears in Collections:	Research articles (Dept of Chemistry)

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