Prenylated chalcones, flavone and other constituents of the twigs of Dorstenia angusticornis and Dorstenia barteri var. subtriangularis

Abstract

The twigs of Dorstenia angusticornis and Dorstenia barteri var. subtriangularis yielded 16 compounds. Two novel diprenylated chalcones: 3,50-di-(2-hydroxy-3-methylbut-3-enyl)-4,20,40-trihydroxychalcone, 3, 4-(2,2-dimethylpyrano)-30-(2-hydroxy-3-methylbut- 3-enyl)-20,40-dihydroxychalcone and the known stipulin were isolated from both species. 3-(2-Hydroxy-3-methylbut-3-enyl)- 50-(3,3-dimethylallyl)-4,20,40-trihydroxychalcone and the known compounds: 4-hydroxylonchocarpin, kanzonol B, bartericins A, B, C and 30-(2-hydroxy -3-methylbut-3-enyl)-4,20,40-trihydroxychalcone were isolated from D. barteri while the known compounds: gancaonin Q, paratocarpins C, F, and lupeol were obtained from Dorstenia angusticornis. b-Sitosterol and its b-D-glucopyranoside were isolated from both species. Structures of these secondary metabolites were established using spectroscopic analysis, especially, NMR spectra in conjunction with 2D experiments, COSY, HMQC and HMBC.