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http://hdl.handle.net/10311/299
Title: | Antimicrobial and antioxidant flavonoids from the root wood of Bolusanthus speciosus |
Authors: | Erasto, P. Bojase-Moleta, G. Majinda, R.T. |
Keywords: | Bolusanthus speciosus Fabaceae Root wood Flavonoids 5,7,4'-Trihydroxy-6-[1-hydroxy-2-methylbuten-2-yl]isoflavone 7,20-Dihydroxy-4'-methoxyisoflav-3-ene 6,60-Dihydroxy-40-methoxy-2-arylbenzofuran Antimicrobial radical scavenging properties |
Issue Date: | 2004 |
Publisher: | Elsevier Ltd. www.elsevier.com/locate/phytochem |
Citation: | Erasto, P, et al (2004), Antimicrobial and antioxidant flavonoids from the root wood of Bolusanthus speciosus, Phytochemistry, vol. 65, pp. 875-880 |
Abstract: | Three new flavonoids-5,7,4'-trihydroxy-6-[1-hydroxy-2-methylbuten-2-yl]isoflavone (isogancaonin C), 7,2'-dihydroxy-4'-methoxyisoflav- 3-ene (bolusanthin III), 6,6'-dihydroxy-4'-methoxy-2-arylbenzofuran (bolusanthin IV), in addition to eight known flavonoids; derrone, medicarpan, genistein, wighteone, lupiwighteone, gancaonin C, 7-hydroxy-4'-methoxyisoflavone and 7,3'-dihydroxy-4'- methoxyisoflavone were isolated from the root wood of Bolusanthus speciosus.The compounds showed strong antimicrobial activity against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Candida mycoderma.The isolated compounds also showed moderate to strong radical scavenging properties against DPPH radical with the highest activities shown by the 2-arylbenzofuran, the isoflav-3-ene and 7,3'-dihydroxy-4'-methoxyisoflavone in decreasing order. |
URI: | http://hdl.handle.net/10311/299 |
ISSN: | 0031-9422 |
Appears in Collections: | Research articles (Dept of Chemistry) |
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