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dc.contributor.authorKeter, F.K.
dc.contributor.authorOjwach, S.O.
dc.contributor.authorOyetunji, O.A.
dc.contributor.authorGuzei, I.A.
dc.contributor.authorDarkwa, J.
dc.date.accessioned2012-11-06T07:06:13Z
dc.date.available2012-11-06T07:06:13Z
dc.date.issued2009
dc.identifier.citationKeter, F.K. et al. (2009) Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with L-cysteine, Inorganica Chimica Acta, Vol. 362, No. 8, pp. 2595–2602en_US
dc.identifier.issn0020-1693
dc.identifier.urihttp://hdl.handle.net/10311/1032
dc.description.abstractA series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl2(3,5-R2bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl2(3,5-R2bpza)] {R = H (3a), R = Me (4)}, [AuCl2(3,5- R2bpza)]Cl {R = H (5a), R = Me (6a)} and [PdCl2(3,5-R2bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N^N-coordination with the metals. Anticancer activities of six complexes 1–6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with L-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities.en_US
dc.language.isoenen_US
dc.publisherElsevier Science Ltd, www.elsevier.com/locate/icaen_US
dc.subjectBis(pyrazolyl)acetic acid compoundsen_US
dc.subjectCytotoxicityen_US
dc.subjectPseudo first-orderen_US
dc.subjectSubstitutionen_US
dc.subjectL-cysteineen_US
dc.titleBis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with L-cysteineen_US
dc.typePublished Articleen_US
dc.linkhttp://ac.els-cdn.com/S0020169308006993/1-s2.0-S0020169308006993-main.pdf?_tid=6ba78650-136f-11e2-a410-00000aab0f02&acdnat=1349938184_2795d7e8cd597c5022ef689c82b51682en_US


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