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dc.contributor.authorWale, Kabo
dc.contributor.authorKwape, Tebogo Elvis
dc.contributor.authorSethibe, Laurah
dc.contributor.authorGaobotse, Goabaone
dc.contributor.authorLoeto, Daniel
dc.contributor.authorSethebe, Bongani
dc.date.accessioned2018-11-26T06:42:10Z
dc.date.available2018-11-26T06:42:10Z
dc.date.issued2018-11-10
dc.identifier.citationWale, K. et al. (2018) Antibacterial and antioxidant potential of Albizia anthelmintica as a medicinal plant on pathogenic veterinary isolates. Journal of Medicinal Plants Research, Vol. 12, No. 27, pp. 456-462en_US
dc.identifier.issn1996-0875
dc.identifier.urihttp://hdl.handle.net/10311/1851
dc.description.abstractAlbizia anthelmintica is a medicinal plant belonging to the Fabaceae family. It is widely used by smallholder farmers and pastoralists to treat internal parasites in their livestock. This study aimed to determine the antibacterial and antioxidant potential of A. anthelmintica on pathogenic veterinary isolates. 100% hexane (He100), 100% chloroform (Ch100), 100% ethanol (E100), and 70% ethanol (E70) extracts of the roots and barks of A. anthelmintica were tested against four bacterial strains (Escherichia coli, Clostridium perfringens, Salmonella enterica serovar Typhimurium and Proteus mirabilis). Thin layer chromatography- 2, 2-diphenyl-1- picryl hydrazyl (TLC-DPPH) assay was used to examine antioxidant potential of extracts. Antimicrobial activity was determined using the disc diffusion method and minimum inhibiting concentrations (MICs) values were determined using the micro-titre broth-dilution method. At a concentration of 500 μg/ml, E70 roots extract showed the highest % DPPH inhibition of 66.9%. Among the bark extracts, the highest free radical scavenging activity was observed in E70 extracts with 58.9% DPPH inhibition. Phytochemical analysis of the plant extracts revealed the presence of compounds which are known to exhibit medicinal properties such as tannins, terpenoids, quinones, saponins and fatty acids phenols. E100 bark extracts contained most of these compounds except flavonoids. Only alkaloids were not detected in any of the roots or bark extracts. Ch100 bark extracts showed the highest antimicrobial activity and all bacterial isolates were resistant to the E100 root extracts. Ch100 root extracts showed the lowest minimum inhibition concentration of 0.625 mg/ml against S. enterica serovar Typhimurium. Findings of this study show that some of the root and bark extracts of the A. anthelmintica plant have both antimicrobial and antioxidant properties. These findings can possibly be relevant in the development of novel medication against veterinary pathogens. Furthermore, this study will guide similar studies.en_US
dc.language.isoenen_US
dc.publisherAcademic Journals, https://academicjournals.org/en_US
dc.subjectAntibacterialen_US
dc.subjectantioxidanten_US
dc.subjectAlbizia anthelminticaen_US
dc.subjectphytochemicalen_US
dc.subjectminimum inhibitory concentrations (MICs)en_US
dc.titleAntibacterial and antioxidant potential of Albizia anthelmintica as a medicinal plant on pathogenic veterinary isolatesen_US
dc.typePublished Articleen_US
dc.linkhttps://academicjournals.org/journal/JMPR/article-full-text-pdf/84D374D58917en_US


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