Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii
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Date
2003Author
Dufall, K.
Ngadjui, B.
Simeon, K.
Abegaz, B.
Croft, K.
Publisher
Elsevier Science Ireland Ltd. www.elsevier.com/locate/jethpharmType
ArticleMetadata
Show full item recordAbstract
The antioxidant activities of three prenylated flavonoids from Dorstenia mannii (6,8-diprenyleriodictyol, dorsmanin C and dorsmanin F)
were compared to the common, non-prenylated flavonoid, quercetin. The prenylated flavonoids were found to be potent scavengers of the stable
free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), and are more potent than butylated hydroxy toluene (BHT), a common antioxidant used
as a food additive. The prenylated flavonoids also inhibited Cu2+-mediated oxidation of human low density lipoprotein (LDL). Dose-response
studies indicated that the prenylated flavonoids were effective inhibitors of lipoprotein oxidation with IC50 values <1 M and had similar
inhibitory potency compared to quercetin, but was not directly related to Cu binding. Unlike quercetin, they did not show any pro-oxidant
activity at high doses in the Cu2+-mediated lipoprotein oxidation system. The medicinal action of Dorstenia mannii may be related to the
high concentration of potent antioxidant prenylated flavonoids in this species.